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Unveiling the intricate dance of cellular communication, Alfred G. Gilman and his Nobel Prize-sharing colleagues unlocked the secrets of G-proteins, the molecular maestros that orchestrate signal transduction within cells. Their groundbreaking discovery illuminated how external stimuli trigger cascades of intracellular responses, shaping everything from sensory perception to hormone regulation. This fundamental knowledge transformed our understanding of cellular physiology and opened new avenues for therapeutic interventions.