Answer
The Chiefs were the opponents against whom Andrew Luck led the second-largest comeback in NFL history. Luck's Indianapolis Colts trailed by 28 points early in the second quarter before rallying to win 35-33 on November 4, 2018. Luck passed for 464 yards and four touchdowns with no interceptions in the victory. It was the third-largest comeback in NFL history at the time but would be surpassed three weeks later.