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Roger Federer, the Swiss tennis icon, holds a remarkable record against Andy Roddick, famously defeating him in four major finals: Wimbledon in 2004 and 2005, the US Open in 2006, and Wimbledon once again in 2009. Federer's dominance over Roddick in these pivotal matches showcased his exceptional talent and skill on the court, contributing to his status as one of the greatest tennis players of all time.