Answer
Lasting four years, Antiochus III's war against the Roman Republic, known as the Roman-Seleucid War, took place from 192 to 188 BCE. It marked a critical juncture in Mediterranean history, pitting the expanding Roman Republic against the Hellenistic Seleucid Empire. The conflict arose due to competing interests in Greece and Asia Minor, ultimately resulting in a Roman victory and the Treaty of Apamea, which significantly weakened the Seleucid Empire.