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In the 2003 American romantic comedy film "How to Lose a Guy in 10 Days," Bebe Neuwirth portrayed the character of Lana Jang, a high-powered businesswoman and the editor-in-chief of a fashion magazine. Neuwirth's portrayal of Jang brought depth and humor to the film, with her character serving as a mentor and confidante to the protagonist, Andie Anderson (played by Kate Hudson).