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In the movie "Night at the Museum," Bill Cobbs portrayed the character Reginald, a miniature cowboy who comes to life at night along with other museum exhibits. Reginald is a loyal and enthusiastic companion to the protagonist, Larry Daley (Ben Stiller), and provides comic relief throughout the film. Cobbs' performance as Reginald is both charming and memorable, adding to the overall enjoyment of the movie.