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Denise Darvall, a 22-year-old woman, became the heart donor for the first successful human heart transplant. Her tragic death in a car accident in 1967 led to her heart being used to save the life of 54-year-old Louis Washkansky. The transplant, performed by Dr. Christiaan Barnard in Cape Town, South Africa, was a groundbreaking medical achievement that paved the way for countless future heart transplants.