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Kraft assumed the directorship of the Mission Control Center in 1972. During his time there, he oversaw several successful space missions, including Apollo 16, Apollo 17, Skylab 2, Skylab 3, Skylab 4, the Apollo-Soyuz Test Project, and Space Shuttle missions STS-1 and STS-2. He played a crucial role in ensuring the smooth execution and success of these missions, contributing significantly to NASA's space program.