Answer
Colin Kaepernick made his first NFL start against the St. Louis Rams in week 11 of the 2012 season. He was the backup to Alex Smith, who had started the previous 10 games. Kaepernick played well in his first start, completing 16 of 23 passes for 243 yards and two touchdowns. He also rushed for 18 yards and a touchdown. The 49ers won the game by a score of 24-21.