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São Paulo is the Brazilian club where Lugano played twice. The Uruguayan defender had two stints with the São Paulo club, first from 2003 to 2006 and then again from 2016 to 2017. During his time with São Paulo, Lugano won several titles, including the Campeonato Brasileiro Série A in 2006 and 2017, and the Copa Libertadores in 2005.