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The 2022 U.S. Senate election in Missouri was won by Republican Eric Schmitt, who emerged victorious in a competitive race against Democrat Trudy Bush Valentine. Schmitt, serving as Missouri's Attorney General at the time, secured the victory with a significant margin, garnering 56.2% of the votes compared to Valentine's 41.4%. The election was closely watched as it was seen as one of the most competitive Senate races in the nation.