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In 2011, Eugene Domingo was awarded Best Actress at the Cinemalaya Independent Film Festival for her portrayal in "Ang Babae Sa Septic Tank." The film, directed by Marlon Rivera, tells the story of a woman who accidentally falls into a septic tank and the subsequent events that ensue as she tries to escape. Domingo's performance is both comedic and poignant, capturing the character's resilience and determination amidst absurd circumstances.