Which siege marked the end of Francis, Duke of Guise's military career?
Siege of Calais
Siege of Boulogne
Siege of Orleans
Siege of Rouen
Answer
The Siege of Orleans in 1563 marked the end of Francis, Duke of Guise's military career. He was assassinated during the siege by a Huguenot supporter, which further escalated tensions between Catholics and Protestants in France.
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