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Which siege marked the end of Francis, Duke of Guise's military career?

  • Siege of Calais

  • Siege of Boulogne

  • Siege of Orleans

  • Siege of Rouen

Answer

The Siege of Orleans in 1563 marked the end of Francis, Duke of Guise's military career. He was assassinated during the siege by a Huguenot supporter, which further escalated tensions between Catholics and Protestants in France.
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