Who was Francis, Duke of Guise's wife?
Anne d'Este
Catherine de' Medici
Diane de Poitiers
Marie de Guise
Answer
Francis, Duke of Guise, married Anne d'Este in 1548. Anne was the daughter of Ercole II d'Este, Duke of Ferrara, and Renée of France. Their marriage further strengthened the Guise family's influence in French politics and society.
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