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John Malkovich and Gary Sinise starred together in the 1992 film Of Mice and Men. The film was based on the novella of the same name by John Steinbeck. Malkovich played the role of Lennie Small, a mentally disabled man who befriends George Milton, played by Sinise. The film was well-received by critics and audiences alike, and was nominated for three Academy Awards, including Best Picture.