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Annihilation is a 2018 American science fiction psychological thriller film directed by Alex Garland and written by Garland and Jeff VanderMeer, based on VanderMeer's 2014 novel of the same name. The film stars Natalie Portman, Jennifer Jason Leigh, Gina Rodriguez, Tessa Thompson, Tuva Novotny, Oscar Isaac, and Benedict Wong. The story follows a team of scientists who enter an alien zone known as "The Shimmer".