Answer
Hephaestion's wife was related to Alexander how? Hephaestion's wife, Drypetis, was the sister of Alexander's second wife, Roxana. She was also the daughter of Oxyartes, the ruler of Sogdiana. Hephaestion and Alexander were close friends, and Alexander was devastated when Hephaestion died in 324 BC. After Hephaestion's death, Alexander married Roxana, and Drypetis became his sister-in-law.