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Isaac Cuenca made his first team debut for Barcelona in the 2011-2012 season. He was promoted to the first team from the Barcelona B team, where he had been playing since 2009. Cuenca made his debut in a La Liga match against Real Sociedad on 20 August 2011, and he scored his first goal for the club in a Champions League match against Viktoria Plzeň on 13 September 2011.