Answer
The revolutionary genome editing tool CRISPR-Cas9 was first proposed for use in a groundbreaking research paper co-authored by Jennifer Doudna and Emmanuelle Charpentier. This seminal work, published in the prestigious journal Science in 2012, outlined the potential of CRISPR-Cas9 as a precise and versatile gene-editing technology, sparking a scientific revolution and opening up new avenues for research and therapeutic applications.