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Jane Nebel collaborated with Jim Henson on the creation of Sam and Friends, a groundbreaking puppet show that aired from 1955 to 1961. Nebel, a puppeteer and voice actress, brought her expertise in puppetry and character development to the show, working alongside Henson to create memorable characters like Kermit the Frog and Miss Piggy. Their collaboration laid the foundation for Henson's future success with The Muppets.