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Grandpa Lou Pickles, the cantankerous and often misunderstood grandfather of Tommy Pickles, was originally voiced by Joe Alaskey. Alaskey took over the role in 1993 after the original voice actor, David Doyle, passed away. Alaskey's portrayal of Grandpa Lou brought a unique blend of humor and warmth to the character, making him a beloved figure among fans of the show.