Marisa Tomei played Reilly's love interest in "Cyrus". Tomei is an American actress who has appeared in numerous films and television shows. She is best known for her roles in "My Cousin Vinny" (1992), for which she won an Academy Award for Best Supporting Actress, and "The Wrestler" (2008), for which she was nominated for an Academy Award for Best Supporting Actress.
The Remarkable Journey of John C. Reilly: An Engaging English Quiz on the Versatile American Actor (Born 1965)