Answer
Robert Gottlieb, an editor at Simon & Schuster, rejected "A Confederacy of Dunces" after several revisions. Despite the author's efforts to address Gottlieb's critiques, Gottlieb found the novel's protagonist, Ignatius Reilly, too unlikable and the plot too chaotic. The rejection ultimately led to the novel's publication after the author's death, when it became a critical and commercial success.