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Flamengo was the last coaching position held by Sampaoli as of 2023. He was appointed as the head coach of the Brazilian club in December 2022, replacing Dorival Júnior, who had led the team to the Copa Libertadores and Copa do Brasil titles in the same year. Sampaoli's tenure at Flamengo, however, was short-lived, as he left the club in July 2023 after a string of poor results.