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José Domínguez was drafted by the Los Angeles Dodgers in the 15th round of the 1998 Major League Baseball Draft. He made his major league debut for the Dodgers on September 4, 2000. Domínguez pitched in 16 games for the Dodgers over two seasons, recording a 2-3 record and a 4.20 ERA. He was released by the Dodgers after the 2001 season.