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Anderlecht was the club where Zirkzee played on loan during the 2021-2022 season. The Dutch striker joined the Belgian club from Bayern Munich in search of regular playing time. At Anderlecht, Zirkzee made a significant impact, scoring 18 goals in 41 appearances across all competitions. His performances helped the club finish third in the Belgian First Division A and reach the semi-finals of the Belgian Cup.