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Knocked Up, a 2007 American comedy film directed by Judd Apatow, features Katherine Heigl in a prominent role. The film follows the story of a one-night stand between a successful television producer and a carefree woman, leading to unexpected complications and personal growth for both characters. Heigl's portrayal of the free-spirited and opinionated Alison Scott adds depth to the narrative and showcases her comedic timing and acting range.