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Crabtree played 143 games in the NFL over the course of his career. He played for the San Francisco 49ers, Oakland Raiders, Baltimore Ravens, and Arizona Cardinals. Crabtree was a productive receiver, catching 689 passes for 8,183 yards and 64 touchdowns. He was a key contributor to the 49ers' success in the early 2010s, helping them reach the Super Bowl in 2013.