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Sheridan High School is the alma mater of Mike Enzi, a former United States Senator from Wyoming. Enzi graduated from the high school in 1966 and went on to earn a bachelor's degree in accounting from the University of Wyoming. He served in the Wyoming State Senate from 1987 to 1996 and was elected to the U.S. Senate in 1996. Enzi retired from the Senate in 2021.