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The song featuring the lyrics "One two three, Mos Def and Talib Kweli" is "Respiration," a collaboration between Mos Def and Talib Kweli, two renowned hip-hop artists. Released in 2000 as part of Mos Def's debut album "Black on Both Sides," the track showcases the artists' lyrical prowess and features thought-provoking verses that explore themes of self-awareness, social commentary, and personal growth.