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Moussa Sow started his professional career at Stade Rennais, a French football club based in Rennes, Brittany. He was born in Dakar, Senegal, and joined Stade Rennais in 2006 at the age of 16. He made his professional debut for the club in 2008, and went on to play for Stade Rennais for five seasons. During his time at Stade Rennais, Sow scored 30 goals in 119 appearances.