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The Edisto River is a prominent river that runs through Orangeburg, South Carolina. Originating in the state's midlands near Saluda and Edgefield counties, the Edisto flows south-southeast for approximately 250 miles before meeting the Atlantic Ocean near Edisto Beach. With its headwaters in the state's Sandhills, the river is significant for providing drinking water, irrigation, and recreational activities to the communities it traverses.