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Early-onset Alzheimer's Disease, a progressive neurodegenerative disorder that affects memory, thinking, and behavior, ultimately led to Pat Summitt's retirement from coaching women's basketball at the University of Tennessee. Summitt, a legendary figure in the sport, announced her diagnosis in 2011 and continued to coach for several more seasons before stepping down in 2012. Her courageous battle with Alzheimer's raised awareness of the disease and inspired many.