Answer
Lethal Weapon 4, the 1998 sequel to the popular action franchise, featured Rene Russo in a prominent role. Russo played Lorna Cole, a psychiatrist who becomes romantically involved with Mel Gibson's character, Martin Riggs. The film follows the LAPD detectives as they investigate a smuggling ring while dealing with personal challenges, including Riggs's struggles with PTSD and Cole's own troubled past.