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In the critically acclaimed 2000 American comedy-drama "Nurse Betty," Renée Zellweger delivers an exceptional performance that earned her the Golden Globe Award for Best Actress in a Motion Picture - Comedy or Musical. Zellweger's portrayal of Betty Sizemore, a naïve soap opera fan who embarks on an extraordinary adventure following a traumatic event, showcases her versatility and ability to bring endearing charm and depth to her characters.