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What year was the Heck reaction first published?

  • 1968

  • 1972

  • 1976

  • 1980

Answer

The Heck reaction, first reported in 1968, is a palladium-catalyzed carbon-carbon bond-forming reaction involving an aryl or vinyl halide and an alkene or alkyne. It is widely used in organic synthesis for the construction of various carbon-carbon bonds, particularly in the pharmaceutical and agrochemical industries. The reaction proceeds via a catalytic cycle involving oxidative addition, insertion, and reductive elimination steps.
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From Catalysts to Chemistry: Unraveling the Genius of Richard F. Heck

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