What is the first element of Robinson's famous annulation sequence?
Cyclization
Oxidation
Halogenation
Polymerization
Answer
Cyclization refers to the first step of Robinson annulation, a multi-step organic reaction sequence involving intramolecular aldol condensation. Beginning with the reaction of a ketone enolate with an aldehyde or ketone, the process results in the formation of a new carbon-carbon bond and the construction of a cyclic structure.
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