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Ryan Preece's NASCAR Cup Series career began with the Ford Mustang. He made his debut at the 2019 season-opening Daytona 500, driving the No. 47 JTG Daugherty Racing entry. Preece competed full-time in the Cup Series for two seasons with JTG Daugherty, primarily driving the No. 37 Ford Mustang. During his tenure, he had several top-10 finishes and earned Rookie of the Year honors in 2019.