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Sam Levene's career spanned five decades, from the 1920s to the 1960s. He began his career as a vaudeville performer and later transitioned to Broadway, where he became known for his comedic roles. Levene also appeared in numerous films and television shows, including "Guys and Dolls" (1955) and "The Producers" (1968). He was nominated for an Academy Award for Best Supporting Actor for his role in "The Producers."