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After retiring as a player, Sami Hyypiä transitioned into a managerial role at Bayer Leverkusen. He served as the club's manager from 2012 to 2014, overseeing the team's performances and tactical decisions. During his tenure, he guided Leverkusen to a third-place finish in the Bundesliga and a runner-up position in the DFB-Pokal.