Which 49ers running back set the NFL record for most rushing yards in a single game in 2000?
Garrison Hearst
Roger Craig
Frank Gore
Charlie Garner
Answer
Charlie Garner set the NFL record for most rushing yards in a single game with 251 yards on September 23, 2000, against the Dallas Cowboys. Garner played for the 49ers from 1999 to 2000.
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