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The Hiss-Chambers case was a significant event during the Red Scare, a period of heightened fear and suspicion of communist influence in the United States. The case involved Whittaker Chambers, a former Soviet spy who accused Alger Hiss, a high-ranking State Department official, of being a communist spy. The ensuing trials and investigations captivated the nation and contributed to the atmosphere of paranoia and distrust that characterized the Red Scare.