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Janssen helped Monterrey win the CONCACAF Champions League in 2021, scoring a goal in the second leg of the final against América. This was the first time that Monterrey had won the tournament since 2011, and it was Janssen's first major honour with the club. The victory also qualified Monterrey for the 2021 FIFA Club World Cup, where they were eliminated in the semi-finals by Al Ahly of Egypt.