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Being John Malkovich, Spike Jonze's directorial debut from 1999, features Catherine Keener in a prominent role. The film delves into the surreal and psychological realm of a puppeteer who discovers a portal that allows people to enter the mind of actor John Malkovich. Keener portrays Maxine, the eccentric wife of the puppeteer, adding to the film's unconventional and thought-provoking narrative.