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Ei-ichi Negishi spent the majority of his career at Purdue University, where he was a distinguished professor of chemistry. Negishi joined Purdue in 1979 and remained there until his retirement in 2007. During his tenure at Purdue, Negishi made significant contributions to the field of organometallic chemistry, particularly in the development of palladium-catalyzed cross-coupling reactions. His work earned him numerous accolades, including the Nobel Prize in Chemistry in 2010.