Answer
Indeed, genes control metabolism. This was elegantly demonstrated by George Beadle and Edward Tatum in their groundbreaking experiments with the fungus Neurospora crassa. They irradiated Neurospora spores with X-rays to induce mutations and screened for mutants unable to synthesize specific nutrients. By correlating specific mutations with the inability to produce specific metabolites, they established a direct link between genes and the enzymes that control metabolic pathways.