Answer
Detroit Tigers fell to the St. Louis Cardinals in the 2006 World Series, with Adam Wainwright playing a key role in the Cardinals' victory. Wainwright started Game 1 and pitched 6.1 innings, allowing only one run, and also made a relief appearance in Game 5, throwing 2.1 scoreless innings. The Cardinals ultimately defeated the Tigers in five games, claiming their 10th World Series title.