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The 2001 Copa Libertadores final second leg took place at the Azteca Stadium in Mexico City. The match was between Boca Juniors and Cruz Azul, and it was a rematch of the first leg, which Boca Juniors had won 2-0. Cruz Azul won the second leg 1-0, but Boca Juniors won the tie on aggregate and claimed their fifth Copa Libertadores title.