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The title role in Brian De Palma's "Carrie" (1976) was portrayed by Sissy Spacek, an American actress known for her versatility and compelling performances. Spacek's portrayal of the tormented teenager Carrie White, who possesses telekinetic powers, garnered critical acclaim and solidified her status as a rising star in Hollywood. Her sensitive and nuanced performance captured the character's internal struggles, making "Carrie" a memorable and impactful cinematic experience.