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The setting of "The Sheltering Sky" is French North Africa, primarily in Algeria and the Sahara Desert. The story follows the travels and experiences of a couple, Port and Kit Moresby, as they journey through the vast and unforgiving landscapes, encountering cultural clashes, personal conflicts, and the challenges of their own relationship. The novel explores themes of alienation, existentialism, and the search for meaning in a harsh and unforgiving environment.